Italian nobleman of the powerful House of Medici, he was the ruler of Florence from 1516 until his death in 1519. He was also Duke of Urbino during the same period. His daughter Catherine de’ Medici became Queen Consort of France, while his illegitimate son, Alessandro de’ Medici, became the first Duke of Florence.
Lorenzo was a son of Piero di Lorenzo de’ Medici and Alfonsina Orsini. His paternal grandparents were Lorenzo the Magnificent and Clarice Orsini.
In 1510, while the Medici family were living near Rome, a black servant in their household – identified in documents as Simonetta da Collevecchio – gave birth to a son, Alessandro de’ Medici, whom Lorenzo officially recognized as his illegitimate son. In 1531, Alessandro de’ Medici became Florence’s first hereditary monarch.
On 13 June 1518, Lorenzo married Madeleine de la Tour, daughter of the Count of Auvergne. The marriage produced a daughter, Catherine, who was born in 1519. Catherine de’ Medici went on to become Queen of France, via a marriage to the future King Henry II of France, arranged by the second Medici Pope, Pope Clement VII.
Only 21 days after Catherine de’ Medici’s birth, Lorenzo II died, “worn out by disease and excess”, on 4 May 1519 at age 26 in Careggi, Republic of Florence. Thus his daughter Catherine was raised primarily by the Medici Popes, Leo X and Clement VII, and their surrogates.

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