British-Irish fashion designer, model, artist, philanthropist and muse to artists ranging from Karl Lagerfeld to Lady Gaga.
Her father is Jonathan Guinness, 3rd Baron Moyne, the eldest son of Diana Mitford Mosley and Bryan Guinness. Daphne’s mother, Jonathan’s second wife, was Suzanne Lisney (died 2005), of Cadaques, Spain, and Paris. Lisney was an artist and muse to Man Ray and Dalí.
An icon in the world of fashion, she is courted by many of the best-known names in fashion (such as Karl Lagerfeld, NARS, MAC, Akris, Gareth Pugh and Philip Treacy), working with them artistically or as a model or both. Her best-known friend was the late fashion designer Alexander McQueen.
She creates and invents many objects herself, many inspired by her fascination with armour. She is known for a taste for skinny pants and platform pumps. She designs fashion, jewelry, and perfume for herself when she cannot find exactly what she wants to wear or buy. She has said that she created more than 100 pieces in 2010 alone.
Guinness has been involved in numerous philanthropic efforts, such as when she walked in two of Naomi Campbell’s Fashion for Relief shows with the purpose of raising funds for disaster victims. In June 2010, she purchased the entire lot of the wardrobe of Isabella Blow, her friend who committed suicide in 2007. Guinness held an auction in 2012 where she raised $744,285 for the Isabella Blow Foundation.
In 1985, when she moved to New York City, she “inherited” many of her sister Catherine’s friends including Andy Warhol, for whom her sister had been a personal assistant for many years. In 1987, she married Spyros Niarchos, the second son of Stavros Niarchos, the shipping magnate. They divorced in 1999. Nowadays she lives in London and Manhattan with her three children: Nicolas Stavros Niarchos (born 1989), Lex Spyros Niarchos (born 1991), and Ines Sophia Niarchos (born 1995). She has been romantically involved with French TV philosopher Bernard-Henri Lévy for a number of years.

Link to Wikipedia biography